Mirco Ponzoni Selected Research

EZN-2208

9/2011	Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects.
10/2010	Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.

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Mirco Ponzoni Research Topics

Disease

63	Neuroblastoma 12/2023 - 01/2003
62	Neoplasms (Cancer) 02/2024 - 08/2003
8	Melanoma (Melanoma, Malignant) 08/2021 - 05/2003
5	Lung Neoplasms (Lung Cancer) 02/2022 - 11/2008
4	Carcinogenesis 03/2022 - 02/2005
4	Neoplasm Metastasis (Metastasis) 05/2021 - 10/2003
3	Hypoxia (Hypoxemia) 09/2011 - 05/2009
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/2021 - 11/2014
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 01/2016
2	Fibrosis (Cirrhosis) 01/2017 - 01/2016
2	Necrosis 09/2013 - 10/2010
2	Neuroectodermal Tumors (Neuroectodermal Tumor) 06/2010 - 12/2004

Drug/Important Bio-Agent (IBA)

24	Liposomes (Liposome)IBA 08/2021 - 10/2003
18	Peptides (Polypeptides)IBA 06/2021 - 11/2003
17	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2021 - 01/2003
11	Proteins (Proteins, Gene)FDA Link 12/2023 - 10/2003
11	LigandsIBA 09/2017 - 12/2004
9	FenretinideIBA 08/2021 - 05/2003
7	CD13 Antigens (Alanine Aminopeptidase)IBA 08/2015 - 11/2003
7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2013 - 12/2004
6	RetinoidsIBA 08/2021 - 05/2003
6	AntibodiesIBA 01/2019 - 10/2005
5	MicroRNAs (MicroRNA)IBA 02/2022 - 01/2019
5	Monoclonal AntibodiesIBA 01/2013 - 10/2003
4	liposomal doxorubicin (Doxil)FDA Link 01/2021 - 11/2003
4	Anaplastic Lymphoma KinaseIBA 10/2015 - 06/2011
4	Matrix Metalloproteinases (MMPs)IBA 09/2013 - 12/2004
4	Therapeutic UsesIBA 10/2010 - 07/2007
4	AntigensIBA 07/2010 - 08/2004
3	Topotecan (Hycamtin)FDA LinkGeneric 01/2023 - 10/2010
3	Lipid NanoparticlesIBA 02/2022 - 01/2019
3	FibrinIBA 01/2021 - 06/2019
3	GelsIBA 01/2021 - 06/2019
3	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 11/2015
3	Vinblastine (Vinblastine Sulfate)FDA Link 10/2017 - 10/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2017 - 12/2004
3	SuspensionsIBA 11/2015 - 08/2006
3	Bortezomib (Velcade)FDA Link 08/2015 - 08/2006
3	Protein Isoforms (Isoforms)IBA 04/2015 - 04/2006
3	NGR peptideIBA 09/2012 - 11/2003
3	CaspasesIBA 06/2010 - 08/2006
3	CytokinesIBA 05/2009 - 12/2004
3	OligodeoxyribonucleotidesIBA 02/2008 - 10/2003
3	Antisense OligonucleotidesIBA 10/2005 - 07/2003
2	Immunoconjugates (Immunoconjugate)IBA 01/2023 - 10/2020
2	Temozolomide (Temodar)FDA LinkGeneric 01/2023 - 01/2019
2	CurcuminIBA 01/2023 - 06/2010
2	NucleolinIBA 11/2022 - 06/2021
2	Antineoplastic Agents (Antineoplastics)IBA 03/2022 - 01/2019
2	Tyrosine Kinase InhibitorsIBA 09/2020 - 10/2015
2	CyclodextrinsIBA 12/2019 - 06/2019
2	ProdrugsIBA 01/2019 - 10/2010
2	Neuropilin-1IBA 01/2019 - 11/2018
2	Coloring Agents (Dyes)IBA 11/2018 - 06/2005
2	Isoaspartic Acid (Isoaspartate)IBA 09/2017 - 03/2010
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 09/2017 - 03/2010
2	Histones (Histone)IBA 01/2017 - 10/2010
2	LipidsIBA 01/2016 - 01/2009
2	Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)IBA 01/2013 - 07/2010
2	Small Interfering RNA (siRNA)IBA 12/2011 - 06/2011
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2011 - 06/2011
2	matrigelIBA 09/2011 - 05/2009
2	Irinotecan (Camptosar)FDA LinkGeneric 09/2011 - 10/2010
2	LuciferasesIBA 09/2011 - 10/2010
2	EZN-2208IBA 09/2011 - 10/2010
2	Topoisomerase I InhibitorsIBA 09/2011 - 10/2010
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 10/2010 - 11/2003
2	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 05/2009 - 12/2004
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 05/2009 - 12/2004
2	Sirolimus (Rapamycin)FDA Link 07/2007 - 10/2005
2	Caspase 8 (Caspase-8)IBA 01/2007 - 12/2004
2	DNA (Deoxyribonucleic Acid)IBA 01/2007 - 02/2005
2	Immunoglobulin Fab FragmentsIBA 07/2003 - 01/2003
1	CarbohydratesIBA 12/2023
1	Tetrazolium SaltsIBA 01/2023
1	Docetaxel (Taxotere)FDA Link 01/2023
1	DuocarmycinsIBA 01/2023
1	ChemokinesIBA 11/2022
1	Mitoxantrone (Novantrone)FDA LinkGeneric 11/2022
1	Drug CombinationsIBA 11/2022
1	CSK Tyrosine-Protein KinaseIBA 03/2022
1	pyrimidineIBA 03/2022
1	RNA (Ribonucleic Acid)IBA 03/2022
1	Transcription Factors (Transcription Factor)IBA 11/2021
1	MK-8776IBA 10/2021
1	olaparibIBA 10/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 10/2021
1	Nanoparticle Drug Delivery SystemIBA 08/2021
1	Peptide TIBA 06/2021
1	Surface Antigens (Surface Antigen)IBA 05/2021
1	Glycoproteins (Glycoprotein)IBA 10/2020
1	AgarIBA 06/2019

Therapy/Procedure

33	Therapeutics 01/2023 - 05/2003
11	Drug Therapy (Chemotherapy) 10/2021 - 11/2003
3	Precision Medicine 02/2024 - 09/2022
2	Investigational Therapies (Experimental Therapy) 01/2019 - 07/2003
1	Molecular Targeted Therapy 02/2024
1	Immunomodulation 11/2022
1	Lab-On-A-Chip Devices 11/2022
1	Immunotherapy 11/2022